Summary Safety Review - Atypical antipsychotics - Assessing the potential risk of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Health Canada reviewed the potential risk of DRESS with the use of atypical antipsychotics, following the manufacturers’ voluntary update of the product safety information for Zyprexa (olanzapine) and Zeldox (ziprasidone) to include the risk of DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms). DRESS describes a group of rare but serious and potentially life-threatening side effects to medications, such as fever, severe skin rash with swollen face or peeling of the skin over large areas of the body, etc.

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Champ	Valeur
Dernière modification	avril 17, 2026, 22:00 (TU)
Créé le	avril 17, 2026, 22:00 (TU)
criticality_level	[]
geographic_scope	[]
open_canada_collection	publication
open_canada_date_published	2020-12-04 00:00:00
open_canada_keywords	{"fr": ["Résumé de l'examen de l'innocuité", "antipsychotiques atypiques", "évaluation", "risque potentiel", "réaction médicamenteuse avec éosinophilie et symptômes systémiques", "DRESS", "informations sur la sécurité du produit", "Zyprexa (olanzapine)", "Zeldox (ziprasidone)", "effets secondaires potentiellement mortels", "effets secondaires -effet des médicaments", "fièvre", "éruption cutanée sévère", "visage enflé", "desquamation de la peau"], "en": ["Summary Safety Review", "Atypical antipsychotics", "assessing", "potential risk", "Drug-Reaction-with-Eosinophilia-and-Systemic-Symptoms", "DRESS", "product safety information", "Zyprexa (olanzapine)", "Zeldox (ziprasidone)", "life-threatening side-effects", "side-effect to medications", "fever", "severe skin rash", "swollen face", "peeling of the skin"]}
open_canada_subject	["health_and_safety"]
sensitivity_level	unrestricted
title_fr	Résumé de l’examen de l’innocuité - Antipsychotiques atypiques - Évaluation du risque de syndrome d’hypersensibilité médicamenteuse avec éosinophilie et symptômes généraux (syndrome DRESS)
update_frequency	as_needed