The B.C. nickel water quality guideline (WQG) for the protection of aquatic life was derived in 2024 and uses a biotic ligand model (BLM) to account for site specific toxicity modifying factors such as temperature, pH, dissolved organic carbon (DOC) and hardness. The B.C. nickel BLM software, available on the B.C. WQG website can be used to calculate the nickel WQG if site specific concentrations of the toxicity modifying factors are known. This dataset provides acute WQGs for various concentrations of temperature, pH, DOC and hardness that can be used to look-up WQGs without needing to run the BLM software.