The effects of pharmaceuticals on a unionid mussel (Lampsilis siliquoidea): An examination of acute and chronic endpoints of toxicity across life stages

The toxicity and bioconcentration of 3 pharmaceuticals (amitriptyline, iopamidol, and sertraline) were examined using multiple life stages (larval, juvenile, and adult) of the unionid mussel Lampsilis siliquoidea. The endpoints examined varied with life stage but included survival, behavior (algal clearance rate, filtering frequency), and oxidative stress. Glochidia and juveniles were more sensitive than adult mussels. However, the compounds examined were not toxic at concentrations detected in the environment. The results suggest that glochidia toxicity could be a screening tool for rapidly assessing the toxicity of chemicals of concern to freshwater mussels. Results were published in a scientific article that can be found here: https://doi.org/10.1002/etc.3683

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Additional Info

Field	Value
Last Updated	April 17, 2026, 21:27 (UTC)
Created	April 17, 2026, 21:27 (UTC)
contact_person	{}
criticality_level	[]
data_dictionary	[]
geographic_scope	["0"]
open_canada_collection	primary
open_canada_date_published	2022-02-04 00:00:00
open_canada_keywords	{"fr": ["Amitriptyline", "iopamidol", "sertraline", "produits pharmaceutiques", "bioconcentration", "moule d'eau douce", "Le Bureau de l'évaluation et du contrôle des substances nouvelles (BECSN)", "Écosystème aquatique", "Toxicologie"], "en": ["Amitriptyline", "Iopamidol", "Sertraline", "Pharmaceuticals", "Bioconcentration", "Freshwater mussel", "The New Substances Assessment and Control Bureau (NSACB)", "Aquatic ecosystems", "Toxicology"]}
open_canada_subject	["nature_and_environment"]
sensitivity_level	unrestricted
title_fr	Les effets de produits pharmaceutiques sur une moule unionidée (Lampsilis siliquoidea) : un examen des paramètres de toxicité aigüe et chroniques à différents stades de vie
update_frequency	not_planned