Metformin: Environmental fate and effects on freshwater plankton

Zooplankton and phytoplankton were collected during the 56-day metformin in-lake mesocosm exposure conducted Lake 114 at the International Institute for Sustainable Development-Experimental Lakes Area (IILSD-ELA) in northern Ontario, Canada. Samples were collected three times throughout the exposure (beginning, middle and end) and analysed under microscope to determine species diversity and total counts. Biomass of phytoplankton was also calculated. The experiment consisted of three metformin treatments (0, 4, and 40 μg/L) each with 4 replicates for a total of 12 mesocosms.

Supplemental Information

Supporting projects: Chemicals Management Plan (CMP)

The Chemicals Management Plan (CMP) is a Government of Canada initiative aimed at reducing the risks posed by chemicals to Canadians and their environment. A key element of the Chemicals Management Plan is the monitoring and surveillance of levels of harmful chemicals in Canadians and their environment. Monitoring and surveillance are essential to identify and track exposure to hazards in the environment and associated health implications. Monitoring and surveillance programs provide the basis for making sound and effective public health and environmental health policies and interventions, as well as measuring the efficacy of control measures.

In support of the Chemicals Management Plan, monitoring and surveillance initiatives were established to support Health Canada and Environment and Climate Change Canada scientists, in collaboration with external partners and researchers, to advance our knowledge. This initiative has allowed the Government of Canada to increase its commitment to a number of existing monitoring initiatives, as well as to support new efforts.

For more information on the Chemicals Management Plan, please visit: https://www.canada.ca/en/health-canada/services/chemical-substances/chemicals-management-plan.html

Data and Resources

Additional Info

Field Value
Last Updated April 17, 2026, 20:56 (UTC)
Created April 17, 2026, 20:56 (UTC)
contact_email DRCADonnesOuvertes-ACRDOpenData@ec.gc.ca
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geographic_scope ["0"]
open_canada_collection primary
open_canada_date_modified 2023-11-29 00:00:00
open_canada_date_published 2022-05-22 00:00:00
open_canada_keywords {"fr": ["Environnement", "Eau", "metformine", "phytoplancton", "zooplancton", "écotoxicologie", "produits pharmaceutiques", "eau douce", "Plan de gestion des produits chimiques (PGPC) de Santé Canada", "Bureau de l'évaluation et du contrôle des substances nouvelles (BECSN)"], "en": ["Environment", "Water", "metformin", "phytoplankton", "zooplankton", "ecotoxicology", "pharmaceuticals", "freshwater", "Chemicals Management Plan (CMP) of Health Canada", "New Substances Assessment and Control Bureau (NSACB)"]}
open_canada_subject ["nature_and_environment"]
sensitivity_level unrestricted
title_fr Métformine : Devenir et des effets sur l'environnement du plancton d'eau douce
update_frequency as_needed